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The future, or the "Third Generation," of skin care is the direct intervention in senescence (or the aging process). This technology will do what cosmetics have only promised to do for yearsto dramatically and visibly reduce the appearance of fine lines and wrinkles.

The "first generation" of skin care occurred years ago when cosmetics enhanced the look and feel of the skin indirectly with creams and lotions. Efforts were made to compensate for losses in skin composition by adding moisture and emollient waxes. Unfortunately, these techniques only temporarily improve the "feel" of the skin.

The "second generation" introduced ingredients that protect skin from environmental damage (pollution, free radicals, and UV radiation), which causes premature aging. Products that tout antioxidants and vitamins are in this category. Although protection from environmental factors is a very important part of skin care, these products were not truly "anti-aging."

A more clear understanding of skin biology has allowed scientists to discover the causes of aging at the molecular level.

Naturally programmed into all cells are biologically inherent factors and mechanisms that cause senescence (ageing). New methods of intervention in the aging process at the molecular level are now possible because of this better understanding of the aging process. This we call "The Third Generation" of skin science or Gen III, anti-aging at the cellular level.


Gen III is not a single ingredient but a complex of ingredients. Gen III's effectiveness not only owes itself to the collection of ingredients but its shape is essential to functionality. It takes the form of a liposome, which is a vesicle of phospholipid material, similar to the makeup of the lipids in our own cell membranes.

However, Gen III is a very unique liposome, which has a bipyramidal-angled shape. This design is very complex and is essential for proper delivery to specific functional cells in the skin.

The Gen III liposome also has a special "signaling molecule" which is present on its external wall. It is this "signaling molecule" that makes Gen III an anti-aging revolution.


In the dermis, the lower structural layer of the skin, lies one of the distinctions between young and aged skin.

Fibroblasts in the dermis create collagen fibers and control the makeup and eventual appearance of the skin. Youthful skin contains a predominance of collagen type III, a tensile, flexible, and less fibrous form of collagen. At maturity, cells gradually lose their ability to produce collagen type III through
functional impairment. During the aging process, collagen type III is gradually replaced by collagen type I. In aged skin, collagen type I makes up 80% of dermal collagen while collagen type III accounts for only 15%.

This alteration in dermal (skin) architecture, which is responsible for support of the epidermal surface, causes the major visible differences between young and aged skin. This is one of the major contributors to the gradual formation of fine lines and wrinkles that characterize aged skin.


Technology exists today to modulate or selectively signal and stimulate these dormant functions in the cells that produce collagen type III and other products essential to youthful skin.

Gen III has the ability to stimulate dormant collagen biosynthesis pathways that were naturally turned off by senescence. The mechanism for collagen production still exists, however it remains dormant without proper signaling. Clinical testing has shown that Gen III helps aged skin appear more elastic and smooth, with a reduction in fine lines and wrinkles.

Now let's examine what Gen III will do to the skin from a broader point of view, or more importantly, how will it effect the skin to diminish fine lines and wrinkles and increase the elasticity of the skin? To do this we need to understand some simple anatomy of the skin and what the functional cells in the skin do.

The skin is the largest organ of the body and has a very complex anatomy and physiology. It is in constant repair as it is in contact with the outside environment; therefore, it is composed of many layers. Your skin can be scientifically divided into two major layers, the dermis and the epidermis.

Epidermis: The top layers of the skin make up the epidermis. The epidermis is a mass of cells that continually divide, mature, and migrate to the surface. The functional cells of the epidermis are called Keratinocytes. They originate from stem cells at the basal layer and engage in a maturation process so that when they reach the top, or outside of the skin, they are completely dead and serve as a protection for the body from the outside environment.

Dermis: The dermis lies just beneath the epidermis. It is mainly a matrix of collagen and elastin fibers. The functional cell of the dermis is the "fibroblast." The fibroblast is responsible for depositing the matrix of collagen and elastin. The fibroblasts in the dermis must continually produce collagen and elastin to replace environmentally damaged collagen and elastin that must be eliminated.


As we age, cell turnover in the epidermis slows and the epidermis becomes thinner. Also, the dermal-epidermal border becomes less undulating. Notice the difference in the thickness of the epidermis between the aged skin slide and the youthful skin slide.

old skin - young skin

As we age, collagen and elastin production in the dermis slows down. This has a devastating effect on the look and feel of the skin. Because of the production slowdown, the matrix of collagen and elastin in the dermis is more vulnerable to the outside environment and becomes damaged. As a result, less total collagen and elastin are found in the dermis.

The result is skin that appears more transparent or thin. Damaged collagen results in less elastic skin and more fine lines and wrinkles. Notice the aged skin slide shows empty voids in the dermis where collagen is not present. Collagen also does not stain as brightly as on the youthful skin slide which indicates that the aged skin has an abundance of damaged collagen.


With our current understanding of the differences between young and aged skin we are now ready to look at the anti-aging effects of Gen III.

Clinical Study
Six healthy females, with an average age of 50 years, having wrinkles and dry skin were selected for this study. The subjects applied a Gen III serum to the right side of their face and to the left side they applied a placebo serum containing no Gen III.

After 27 days of treatment, readings were taken to compare the two sides of the face. Skin elasticity was measured using a scientific device called a Cutometer. Clinicians found an average improvement in skin elasticity of 35% compared to data collected on day one.

skin elasticity

Improvement in elasticity is directly related to improvements in the dermal architecture; i.e. increased collagen synthesis and overall improvement in the health of the dermis. This shows that Gen III has a direct effect on the functional cells of the dermis, improving the rebound of the skin making it look and feel younger.

Gen III works without irritation.
Gen III also works without the irritation and photosensitization (sun sensitivity) commonly associated with alpha hydroxy acids, Retin-A, and retinol, which are the most prevalent anti-aging ingredients on the market today. This makes Gen III truly a revolutionary ingredient because it provides extraordinary anti-aging effects without the threat of irritation.

Back from Gen III skin care to Skin care

DNA Repair Creme

DNA Repair Technologya technological breakthrough that actually renews your skin's appearance from the inside out. More...

Skin Products containing Gen III technology:

Delicate Face Cleanser

An extra-mild pH balanced cleanser with antioxidant and nutritive vitamins and botanicals that leave your skin feeling cleansed and refreshed. More...

Revitalizing Toner

Revitalizing Toner is the final step to cleansing. It gently sweeps away pore-blocking impurities, restores pH, and prepares your skin for moisturization. More...

Anti-Aging Serum

Shield your skin from the negative effects of aging and the environment. Anti-Aging Serum with Gen III technology visibly reverses the signs of aging at the cellular level. More...

Advanced Face Cream

Reverse the visible signs of aging with Gen III technology and help your skin achieve its optimum moisture balance. Advanced Face Cream is quickly absorbed. It protects the skin, leaving it soft, radiant, and resilient. More...


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